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Why it matters: Preserves lean muscle mass and bone density Supports metabolic rate Improves satiety without worsening nausea Supports immune function and recovery Protein targets during active weight loss A practical, evidence-aligned approach: 1.2 to 1.6 grams per kilogram of ideal body weight per day during active weight reduction Or an absolute target of 80 to 120 grams per day, which many people find easier to follow For individuals at risk of sarcopenia, aim for at least 1.3 grams per kilogram per day
As a result of the different event rates in the two studies, the median durations of follow-up were also substantially different (3.8 years in LEADER vs
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Glucose regulation mechanisms: GLP-1's primary glucoregulatory effect occurs through glucose-dependent insulin secretion from pancreatic beta cells
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