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Side-by-Side Comparison Parameter Receptors Cagrilintide AMY1R/2R/3R + CTR Semaglutide GLP-1R Tirzepatide GLP-1R + GIPR Retatrutide GLP-1R + GIPR + Glucagon-R Parameter Half-life Cagrilintide ~7-8 days Semaglutide ~7 days Tirzepatide ~5 days Retatrutide ~6 days Parameter Dosing frequency Cagrilintide Once weekly Semaglutide Once weekly Tirzepatide Once weekly Retatrutide Once weekly Parameter Max studied dose Cagrilintide 4.5 mg/week (mono) Semaglutide 2.4 mg/week Tirzepatide 15 mg/week Retatrutide 12 mg/week Parameter Peak monotherapy weight loss Cagrilintide 11.8% at 68 wk Semaglutide 14.9-17% at 68 wk Tirzepatide 22.5% at 72 wk Retatrutide ~24% at 48 wk Parameter FDA status (June 2026) Cagrilintide Investigational Semaglutide Approved (2021) Tirzepatide Approved (2023) Retatrutide Investigational Parameter HbA1c reduction (T2D) Cagrilintide ~0.9 pp mono

Improves gut health: Enhances the health of your digestive system, promoting better nutrient absorption and overall digestive function

Tester feedback from senior news editor Nicola DallAsen When my skin's in serious need of extra TLCas in, spend-an-entire-night-doing-a-12-step-routine seriousthis serum is the first thing I grab after my face is double-cleansed

Symptoms of vitamin B12 deficiency The signs and symptoms of vitamin B12 deficiency include: extreme tiredness weakness pins and needles (especially in your hands and feet) mouth ulcers a swollen and sore tongue (glossitis) blurred vision poor memory depression In rare cases, it can cause heart and fertility problems