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Identification of Small-Molecule Frequent Hitters of Glutathione S-Transferase-Glutathione Interaction
Reactive oxygen species (ROS) is associated with T-cell activation and proliferation, but continued ROS exposure induces T-cell hyporesponsiveness
At the same time, it helps protect skin cells from daily oxidative stress caused by UV rays, pollution, stress, lack of sleep, and ageing, all of which can lead to dullness and uneven skin tone
Investigators use GSH to model cellular redox homeostasis, study Phase II detoxification pathways, and probe protein S-glutathionylation as a post-translational regulatory mechanism
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