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Theoretical concerns in the hepatic-impairment context include: CYP3A4-metabolized drugs whose clearance may shift as liver function changes (not a direct ipamorelin interaction, but co-prescribed agents may behave differently as Child-Pugh stage evolves)

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doi: 10.1016/j.cmet.2012.03.019 36 CastelliSCarinciEBaldelliS

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and I.L

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Treating obesity seriously: when recommendations for lifestyle change confront biological adaptations

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