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Weeks 2-4: Appetite Effects Build, Early Weight Separation What the trials documented: Across the Phase 2 dose-finding trial, weight in the cagrilintide arms began separating from placebo during the initial weeks of titration, with the gap widening at every dose level as the study progressed (Lau et al., 2021)

The dopamine D5 receptor may play an important role in increasing the permeability of duodenal epithelial cells and protecting the colonic mucosa (Li et al., 2019)