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The molecular responses observed vary with receptor subtype, concentration, exposure time, and experimental model, and PT141 is used to characterise melanocortinreceptor signalling rather than to infer defined biological or physiological outcomes
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Interestingly, despite the presence of superoxide dismutase (SOD) ( k = 2.4 10 9 M 1 s 1 ) 36 , the resulting concentration of H 2 O 2 is significantly smaller than the concentration of superoxide, indicating that the model is able to respond well to a transient increase in ROS, maintaining low H 2 O 2 concentrations
