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Tirzepatide is a dual agonist: it acts on GLP-1 and on GIP, a second gut hormone, at the same time

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Since all three medications (Ozempic, Rybelsus, Wegovy) contain semaglutide, can they be used interchangeably

Retatrutide may be worth waiting for if: You have not responded adequately to existing GLP-1 medications Your obesity is severe enough to benefit from the additional weight loss potential You have metabolic dysfunction-associated steatotic liver disease (MASLD/NAFLD) You are comfortable with a medication that has less real-world safety data You can wait for FDA approval without significant health deterioration Your cardiovascular status has been evaluated and heart rate increases are not contraindicated Retatrutide represents the next frontier