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Additionally, Guo and colleagues discovered that microglial exosomes facilitate the transmission of -synuclein (-syn) between cells, contributing to neurodegeneration in the substantia nigra and striatum, which is a significant factor in PD pathogenesis (72)

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Comparative receptor-selectivity studies pairing semaglutide against tirzepatide (dual GLP-1R/GIPR) and retatrutide (triple GLP-1R/GIPR/GCGR) to isolate single-receptor contributions in cell-based reporter assays