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Oxidative stress was also assessed through markers such as nitrotyrosine and 4-hydroxynonenal
For patients who already have diabetic retinopathy or who have struggled with blood sugar control over many years, this is particularly relevant
To address this, they applied a regression-based method (RePACT), which revealed a diabetes-associated epigenetic signature: decreased chromatin accessibility at motifs for HNF1A/B and RFX6, and increased accessibility at motifs for NEUROD1, NFY, and TP53
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