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The reduction of roGFP2(S 2 ) is therefore a good example for an enzyme using an alternative reaction pathway to overcome a kinetic challenge, and we hypothesize that other non-glutathione disulfide substrates with reactive proximal cysteinyl residues and rather negative redox potentials also require a ternary complex for their reduction
doi: 10.3389/fnagi.2024.1444716, 64 HuC.RenC.WuY.LinR.ShenT.LiT.et al
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