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This, in turn, results in impaired proliferation, migration, and differentiation of fibroblasts, and there is an imbalance between matrix-degrading enzymes, MMPs, and their inhibitors, and tissue inhibitor metalloproteinases

Two estimands were employed to assess treatment efficacy from different perspectives and accounted for intercurrent events and missing data differently, as described in a previous publication 31

Sessions typically last 45 to 90 minutes depending on the infusion

Comparison With Other Therapies and Studies in Renal Impairment To judge the positioning of the therapy, a further step in the development of DPP-4 inhibition was comparisons with other therapies