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Some real-world cohorts and long-term extension trials have reported comparable efficacy of biologic agents across BMI categories, especially when weight-based dosing regimens or dose optimization strategies were applied

Chin J Comp Med 2021;31:69-75

Its also linked to metabolic disorders such as diabetes, and has been associated with depression and potentially cancer. Could help lower risk of some cancers A recent study looked at medical records for more than 10,000 people with early-stage cancer and found that those who took GLP-1s had a significantly lower risk of their cancer spreading than those who did not

Active Akt increased the protein levels and transactivation activity of Mash1, 117 suggesting the potential function of the GLP-1-activated PI3K-Akt pathway