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Katz sought feedback from colleagues nationwide, leading to the identification of similar cases

doi:10.5812/ircmj.20781 Khatana C, Saini NK, Chakrabarti S, et al

5,288,289 Oxidative Stress Free radicals, especially oxidized low-density lipoprotein (LDL), promote vascular inflammation, increase the expression of tissue factor on cellular surfaces, damage proteins that regulate coagulation, heighten reactivity of platelets, and disrupt antithrombotic hemostatic mechanisms, raising the risk of thrombosis

These side effects were predominantly mild to moderate in severity and occurred most frequently during the initial dose-escalation period, typically improving with continued treatment