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The key is avoiding a medication-free gap
For tirzepatide users on Mounjaro or Zepbound, you have slightly more flexibility between the stomach and thigh, but the abdomen generally delivers the most consistent results during early dose escalations
335,336 Further, the GLP-1/GIP dual-agonist tested in this study, MAR709, lost its superior efficacy on body weight and food intake over GLP-1 in the CNS-GIPR knockout mice, suggesting that this dual-agonist mediates part of its action via the CNS-GIPR
The earlier 12-week Phase 2a trial had shown encouraging results (2.6 kg vs 0.8 kg for placebo), but the larger, longer, better-powered trial reversed that finding
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