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Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data

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Intranasal delivery of engineered anti-SARS-CoV-2 extracellular vesicles therapeutically represses lung infection and inflammation Summary: We report a first-in-vivo demonstration that intranasally delivered, engineered extracellular vesicles (EVs) carrying a conserved anti-SARS-CoV-2 nanobody (VHH72) can blunt lung infection and dampen inflammation in a mouse model of COVID-19