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In summary, a diverse array of natural products demonstrates potent immunomodulatory effects in PH models, primarily by dampening the activation of innate immune cells, including macrophages and neutrophils, restoring the balance of adaptive immunity such as the Treg/Th17 axis, and disrupting pro-inflammatory cytokine networks, specifically NF-B and NLRP3

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doi: 10.3389/fnut.2023.1134162 Received 30 December 2022 Accepted 22 June 2023 Published 20 July 2023 Volume 10 - 2023 Edited by Xiaoping Yang, Hunan Normal University, China Reviewed by Lorenzo Lorusso, ASST Lecco, Italy

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