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Tirzepatide is a medication that combines the actions of two hormones, GIP and GLP-1, to enhance weight loss and metabolic health

[10] The delayed gastric emptying can also affect medication absorption, which is why the Summary of Product Characteristics advises caution with oral medications that require rapid absorption or have a narrow therapeutic index

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SGLT2 inhibition reduces glucose reabsorption at the level of the proximal renal tubule, promotes urinary glucose excretion independent of insulin action, and causes a negative caloric balance ( Figure 1 )