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Morales J, Assumpcao-Morales M
Pro-inflammatory adipokines (e.g., leptin, resistin) and adipose-derived exosomes (carrying miRNAs like miR-3074-5p) create a chronic inflammatory joint microenvironment by polarizing synovial macrophages toward an M1 phenotype and inhibiting anti-inflammatory adiponectin (1618)
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Monitor for signs of low blood glucose (trembling, sweating, confusion), worsening gastrointestinal symptoms (nausea, vomiting, diarrhoea), severe abdominal pain, signs of liver problems (jaundice, dark urine), or symptoms suggesting altered thyroid function
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