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4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors
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For peptide 20-bound GCGR, its ICL2 moved downward and made extensive polar and nonpolar contacts with the binding groove formed by the N helix, 1 strand and 5 helix of G s , resulting in an ICL2G s interface area of 799 2 , significantly larger than that of GLP-1R (396 2 ) or GIPR (416 2 ) (Fig
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