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The renal fibrosis genes Fn1, Serpine1, Tgfb1, and Col1a1 were downregulated, and the degree of fibrosis was milder

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Combining the in vivo imaging approach with the expression of fluorescent biosensors for different variables of beta and/or alpha cell function and survival, as well as adding genetic manipulation of human islet cells using the CRISPR/cas9 system, will lead to a better understanding of human islet cell biology/pathology and specifically the role of alpha cell-derived paracrine signals for proper beta cell function and survival