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In addition, HIV has been reported to generate massive reactive oxygen and nitrogen species (RONS) associated with HAND, likely by aberrant microglial activation ( FIGURE 1 Recent studies have reported that lysosomal exocytosis is required for oligodendrocytes (OLGc) and Schwan cells myelination, suggesting that dysfunctional ELS could lead to white matter damage in HAND and AD (Shen et al., 2016)
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Furthermore, GLP-1 augments mitochondrial efficacy, as manifested by the ameliorated oxidative metabolism of muscle tissue
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