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In contrast, both dyes co-localized in aberrant-looking vesicles of mitochondrial origin (fragmented mitochondria) (Figure 5.2), disrupting the usual mitochondrial network (Figure 5.3)
In contrast, oxidative stress, DNA damage, or inflammatory stress responses were not activated
Structurally, BPC-157 is notable for a proline-rich backbone (five Pro residues, including a Pro-Pro-Pro triad) together with two acidic Asp residues, one Glu, a single basic Lys, and a hydrophobic C-terminal Leu-Val motif, giving the sequence a distinctive residue distribution relevant to secondary-structure modeling, chromatographic behavior, and mass-spectral fragmentation patterns
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