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The close proximity of the POI and the E3 ligase leads to the ubiquitination of the substrate, followed by proteasomal degradation 33
doi:10.1007/s00259-019-04409-1 151
Management of hyperglycemia in type 2 diabetes: a patient-centered approach: position statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)
In general, all roads lead to Rome and any of these portals can be used to get the medication into the knee joint where it mixes with the synovial fluid and circulates around the knee (thus you dont necessarily have to have an injection on the inside of the knee just because your pain is mostly on the inside)
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