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However, the TMZ in vivo treatment was also showed some improvement on CPT1B but with no significance, which was not consistent with the in vitro result (Figure 5F)

Higher fecal propionate and acetate levels were related to lower resting regulatory T-cells (rTregs) and higher Th17/rTreg ratio in peripheral blood, which showed the mechanism by the interaction of metabolites and immunoregulation (67)