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It has been reported that trastuzumab resistant cells exhibit enhanced glycolysis phenotype, and glycolytic restraint is able to sensitize trastuzumab resistant HER2+ breast cancers to trastuzumab treatment (303)

Upon DNA-dependent transactivation (TA), GR dimers bind to GC-responsive elements, followed by transcriptional activation of genes associated with an increased risk of adverse effects including diabetes mellitus, peptic ulcer, Cushings syndrome, osteoporosis, hyperglycemia, skin and muscle atrophy, and many other complications [12]

Patel R et al

We recommend having a few 3mL or 5mL syringes with a 21-gauge (or similar) needle