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Centrally Mediated Satiety (The Brain Connection) GLP-1 is capable of crossing the blood-brain barrier or signaling via the vagus nerve to reach the hypothalamus, the brains control center
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Figure: Age-adjusted trends in overweight, obesity, and severe obesity among men and women aged 2074: United States, 19601962 through 20172018, CDC Its also very difficult for people who are already obese to sustain significant weight loss, as the body fights very hard to retain fat through its regulatory processes
Psychiatry 181 OLearyT
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