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Clinical Ophthalmology, 1(3), 201207

Vitamin B12 Supplementation in Diabetic Neuropathy: A 1-Year, Randomized, Double-Blind, Placebo-Controlled Trial

1997 May-Oct;91(3-5):139-49

The results showed a significant increase in skin density and thickness, with a 67% reduction in wrinkle volume and improved elasticity, as measured by ultrasound and profilometry (Leyden et al., 2002)