Gallbladder disease (including cholelithiasis and cholecystitis) has been reported in patients taking GLP-1 receptor agonists, particularly in the context of rapid weight loss
Genetics plays a role here, and people who have genetically lower IgE levels are less likely to have chronic urticaria.[ref] Mast cells, atrial fibrillation, and cardiac diseases: Researchers estimate that there are ~50,000 mast cells/g of human heart tissue
Research also shows that several environmental and lifestyle factors can increase the risk of macular degeneration, including smoking, a high-cholesterol diet, carotenoid status, vitamins A and E levels, zinc levels, age, sex, and exposure to heavy metal ions and other chemicals
D., Gordish-Dressman, H., Hoffman, E