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Previous study proved the promising protective effect of UMB against MTX-induced intestinal damage by markedly improved oxidant/antioxidant status, as shown by the parallel decrease in MDA contents and the elevation of Nrf2, SOD, HO-1, and GSH levels
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However, in an alternative indirect mechanism, 25HC binding to site-II could induce conformational changes in the SDL, which may promote efficient high-affinity binding of RGD containing ligands (e.g., fibronectin, laminin etc.) in the site I ligand-binding pocket
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