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Glial cell line-derived neurotrophic factor (GDNF) is an endogenous protector in the mesolimbic system against excessive alcohol consumption and relapse
Metformin carries a boxed warning for lactic acidosis and should not be taken by people with severe renal impairment or acute or chronic metabolic acidosis
The gastrointestinal side effects of Wegovyincluding nausea, vomiting, diarrhoea, and constipationare well-documented and affect a substantial proportion of users, particularly during dose titration
Certain psychiatric medications , including some antipsychotics (olanzapine, clozapine) and mood stabilisers (lithium, valproate), can promote weight gain through mechanisms including increased appetite, insulin resistance, and reduced physical activity
