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Since sertraline targets SHMT systemically, we were interested in the metabolite profiles in the serum of mice with lung tumors that were treated with RT and sertraline as monotherapies, as well as the combination treatment
86 It has been observed in animal models that sustained glucocorticoid stimulation can increase the excitability of glutamatergic neurons and simultaneously decrease the number and plasticity of astrocytes, in addition to decreasing neuronal dendrite connectivity in the hippocampus and frontal cortex, leading to depression
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