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Insulin glargine was not mutagenic in tests for detection of gene mutations in bacteria and mammalian cells (Ames and HGPRT test) and in tests for detection of chromosomal aberrations (cytogenetics in vitro in V79 cells and in vivo in Chinese hamsters)
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PMID 12418503
The FDA is inviting public comments until June 29, 2026, before making a final determination.
However, due to the difficulty in accessing the posterior aspect of the first rib and the middle scalene muscle, the indication has been limited to venous TOS [15,16,17,18,19]
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