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In a large 2-year clinical trial involving 743 patients with a BMI of 2847, those taking orlistat (the active ingredient in Alli) lost, on average, 10.2% of their body weight during the first year, which is significantly more than the 6.1% lost by the placebo group. Patients who continued taking orlistat into the second year regained half as much weight as those who switched to placebo, demonstrating its effectiveness not only for weight loss but also for preventing weight regain. In addition to weight reduction, participants experienced improvements in cholesterol levels, glucose, and insulin concentrations. When used correctly alongside a balanced diet, Alli can be a powerful tool for achieving and maintaining weight loss
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In a rat contusion model of SCI, exenatide administration significantly elevated the expression of M2-associated markers, including Arginase 1, CD163, and CD206, on day 3 post-injury [65]
ION occurs when blood flow to the optic nerve is reduced, damaging the nerve that carries visual information from the eye to the brain
