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As food intake and body weight are controlled by the central nervous system (CNS), understanding the complex CNS mechanisms that regulate energy homeostasis is essential for the discovery of successful antiobesity therapeutics

The palate and the gingiva are the oral mucosal sites most frequently affected

Clinical trials show Mounjaro produced up to 22.5% weight loss, compared with Wegovy's 15% average, though individual responses vary significantly, regardless of which medication shows higher efficacy in controlled studies

For example, coadministration of hPSCs and hydrogels releasing pro-proliferative factors such as Delta-1 has been shown to notably amplify the proliferation of hPSC-CMs post-MI