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Visual characteristics that distinguish potentially malignant lesions include: Appearance : Non-healing ulcers with raised, rolled edges and irregular margins Texture : Firm or indurated upon palpation, unlike the soft texture of benign lesions Color variation : May appear as white, red, or mixed white-red patches (leukoplakia, erythroplakia, or erythroleukoplakia) Location : High-risk sites include the lateral borders of the tongue, the floor of the mouth, and the soft palate Erythroplakia (red patches) carries a significantly higher risk of malignancy than leukoplakia (white patches), with studies showing that up to 90% of erythroplakic lesions harbor severe dysplasia or squamous cell carcinoma on biopsy

Updated June 20, 2025