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doi: 10.1016/S0021-9258(18)42531-8 84 ChenYEDruckerDJ

There additionally exists a safety argument for using MRAs in combination with SGLT2 inhibitors to reduce the risk of hyperkalemia, since the latter medication class has a modest potassium lowering effect as suggested by a recent post hoc analysis of MRA use in DAPA-HF [106]

Orforglipron Orforglipron is a once-daily, oral, non-peptide GLP-1 RA (small molecule) which interacts with the GLP-1 receptor in a slightly different manner compared to native GLP-1

Your eligibility depends on meeting NICE criteria, which typically include inadequate glycaemic control despite other medications or specific BMI thresholds for weight management indications