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It requires a good-faith medical exam by an authorized prescriber, appropriate documentation, and informed consent that presents benefits and risks honestly rather than in an alarmist or oversold way
Moreover, local intracellular accumulation and receptor-independent actions may require higher pharmacological concentrations of melatonin to engage redox-sensitive pathways such as NRF2 compared with approaches which target the central nervous system
This breadth of action may explain why some users respond better to copper peptides when minoxidil hasn't worked
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