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To put it in context, nicotinamide has shown signs of liver toxicity only at doses around 3,000 mg per day or higher
Given the safety, relative low cost, and significant affect cobalamin deficiency can have on quality of life, we recommend B12 supplementation for all emaciated patients, regardless of whether access to serum cobalamin testing is available
Malpractice Exposure: Administering an unapproved Category 2 substance lacking human clinical trials severely compromises a physician's defense in a medical malpractice suit
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