Sustainability 14(18):11536
Ideal candidates have a BMI over 27 with at least one weight-related condition (like high blood pressure or insulin resistance) or a BMI over 30
The cardiovascular outcome data alone, covering nearly 100,000 patients in randomized trials, places this class among the most impactful drug discoveries in modern preventive medicine

What to Try for Mild Symptoms Eat smaller portions and stop at the first sign of uncomfortable fullness Choose lower-fat meals during a flare Eat slowly and chew thoroughly Avoid carbonation, alcohol, and lying down after meals Manage constipation according to your clinicians plan Sip fluids rather than forcing a large amount at once Keep a record of dose, meal, symptoms, bowel movements, and duration Contact the Prescriber Promptly When: Symptoms began or became much worse after a dose increase Burps recur with nausea, reflux, vomiting, constipation, or major fullness You are eating or drinking much less than usual You use insulin, a sulfonylurea, diuretics, laxatives, or medicines affected by delayed gastric emptying Symptoms are affecting work, sleep, nutrition, hydration, or willingness to take the medicine Do not assume severe pain is just sulfur burps Persistent severe abdominal painwith or without vomitingcan be a pancreatitis warning