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MAT1A encodes two liver-specific MAT isoenzymes, such as MATI (MAT1A homo-tetramer) and MATIII (MAT1A homo-dimer), that catalyze the transfer of an adenosyl group of adenosine triphosphate (ATP) to Met to produce SAMe and tripolyphosphate ( MAT2A , and is expressed in all tissues, such as the liver, albeit to a smaller extent ( Figure 1 SAMe serves mainly as a methyl donor in the cell and transfers its methyl group to substrates such as nucleic acids, proteins, lipids, and secondary metabolites with the formation of S-adenosylhomocysteine (SAH, which is also abbreviated as AdoHcy), via transmethylation ( 2
Wang G, Wu Y, Zhou T, Guo Y, Zheng B, Wang J et al
The team's working interest was in cytoprotection , the idea (originating with the Hungarian-Canadian endocrinologist Hans Selye and developed for the gut by Andre Robert) that gastric mucosa contains its own defence machinery against acid, alcohol, and stress