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In addition to the consensus on the prominent role of cystine starvation in blocking GSH synthesis, the present two studies demonstrated two previously under-appreciated metabolic effects that contribute to the ferroptosis-susceptible state in cancer cells under cystine deprivation conditions: loss of GPX4 protein translation and accumulation of oxidative stress-inducing intracellular glutamate (Fig
Not only did she provide effective medical solutions, but she also offered valuable advice on preventive measures to avoid future flare-ups
PubMed Simon A, Emonard H, Hornebeck W, Maquart FX (2000)
The syndrome belongs to a rare disease group, and is thought to be underdiagnosed due to the heterogeneous presentation of symptoms that can be quite atypical
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