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Clinical research spanning multiple decades has documented sermorelin's ability to stimulate the pituitary gland's production of human growth hormone without causing the supraphysiological spikes associated with direct HGH administration
Farr OM, Sofopoulos M, Tsoukas MA, Dincer F, Thakkar B, Sahin-Efe A, Filippaios A, Bowers J, Srnka A, Gavrieli A, Ko BJ, Liakou C, Kanyuch N, Tseleni-Balafouta S, Mantzoros CS (2016) GLP-1 receptors exist in the parietal cortex, hypothalamus and medulla of human brains and the GLP-1 analogue liraglutide alters brain activity related to highly desirable food cues in individuals with diabetes: a crossover, randomised, placebo-controlled trial
March 28, 2025 Update: Plaintiffs in the GLP-1 drug litigation formally opposed efforts by drug manufacturers to dismiss most claims in the consolidated master complaint
This observation holds implications for the design and therapeutic use of positive GLP-1R allosteric modulators
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