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Angiogenic signaling and macrophage recruitment have been proposed as contributing mechanisms

A temporary strange or metallic taste in the mouth has also been noted in some cases immediately after injection, but this is not harmful

Extensively studied in in vitro models for its interactions with the nitric oxide system, VEGF-mediated angiogenesis pathways, and cytoprotective signaling cascades

50 Another RCT reported significant improvements in volume, motility and viscosity of semen, plasma total antioxidant capacity (TAC) and oxidative stress, but not sperm count or morphology with NAC compared with placebo