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Major cardiovascular events, heart failure, and atrial fibrillation in patients treated with glucagon-like peptide-1 receptor agonists: An updated meta-analysis of randomized controlled trials
Critically, a positive feedback loop emerges between accumulated long-chain acylcarnitines and excessive ROS: these acylcarnitines inhibit electron transport chain complex III, inducing ROS overproduction, whereas ROS suppresses CPT2 activity, preventing further metabolism of long-chain acylcarnitines [55, 135,136,137,138]
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