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The substitution of Val by Met modulates both the intracellular trafficking of pro-BDNF and the secretion of mBDNF [110, 156]
This delivery system has been studied a lot
Retatrutide's Phase 2 trial data (Jastreboff et al., NEJM 2023) identified a side-effect profile broadly consistent with other incretin-based therapies: Gastrointestinal : Nausea, vomiting, diarrhoea, and constipation were the most commonly reported adverse effects, particularly during dose escalation
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