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Inhibiting the activity of system Xc- affects the synthesis of GSH by inhibiting the absorption of cystine, which leads to a decrease in GPX activity, a decrease in cell antioxidant capacity, accumulation of lipid ROS, and ultimately the occurrence of oxidative damage and ferroptosis
The take-home message
Nrf2 is a transcription factor from the cap-n-collar family that harbors a unique basic leucine zipper motif and plays as a master regulator of homeostatic responses (Uruno and Yamamoto, 2023)
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