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Financial Times reported this week that Lilly and Novo, the manufacturers of all four GLP-1 drugs commonly used for obesity therapy, are spending $3.5 billion this year to purchase smaller companies with promising anti-obesity therapies

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PI3Ks regulate the activation of macropinocytosis though phosphorylation and activation of phosphatidylinositol [3,4,5]-triphosphate (PIP3) and macropinosome formation involves PIP3 association with actin-rich membrane ruffles in a process that utilize cortical actin which lies just underneath the plasma membrane [74]