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If symptoms persist despite regular oral supplementation, absorption may be limited
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This discovery is particularly relevant in the context of the ingestion analgesia phenomenon, which is related to the suppression of noxious heat-induced withdrawal behaviors in rats during the consumption of chocolate or sweet liquids, in contrast with salt ingestion 3,4,5,6,7
Back in 2010, the US Food and Drug Authority (FDA) concluded that increases in the incidence of carcinomas among rodents translated into a low risk for humans, because statistically significant increases occurred only at drug-exposure levels many times those anticipated in humans
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