By selectively inhibiting NNMT an enzyme central to energy regulation and fat metabolism this compound has demonstrated, in preclinical studies, the capacity to elevate intracellular NAD and SAM levels, suppress lipid accumulation in adipocytes, and reduce white adipose tissue mass in diet-induced obese mouse models
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Additionally, GLP-1RAs interrupt the cycle of hepatocyte apoptosis and the activation of hepatic stellate cells, thereby exhibiting anti-fibrotic properties, as evidenced by the decreased collagen deposition in preclinical studies
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