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Mechanism Comparison: NAD+ Regulation vs Lipotropic Mobilization 5-Amino-1MQ functions as a competitive inhibitor of nicotinamide N-methyltransferase (NNMT), the enzyme that converts nicotinamide (a form of vitamin B3) into N1-methylnicotinamide

In a post hoc analysis after 13 years of the study, a 13% increased risk of vitamin B12 deficiency per year of metformin use was reported (Aroda et al, 2016)

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